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[Association of SPO11 and GST gene polymorphisms with idiopathic male infertility in ethnic Han Chinese].
Feng, Zhanqi; Jing, Zhian; Liu, Hongyan; Liao, Shixiu; Guo, Liangjie; Mao, Changqing; Liu, Yanjun; Wu, Hui; Gao, Jiangtao.
Afiliação
  • Feng Z; Department of Urology, The First People's Hospital of Zhengzhou, Zhengzhou, Henan 450004, P.R. China. fengzhanqi448590@sina.com.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 32(6): 866-70, 2015 Dec.
Article em Zh | MEDLINE | ID: mdl-26663067
OBJECTIVE: To explore the possible roles of polymorphisms of SPO11 and glutathionine S-transferase (GST) genes in idiopathic male infertility in a ethnic Han Chinese population from Henan. METHODS: Multiplex PCR and DNA sequencing were performed to determine the SPO11 c.517C>T(rs28368082) and GST genes (GSTM1, GSTT1, GSTP1) polymorphisms in 216 idiopathic male infertility cases and 198 normal samples. RESULTS: The frequencies of the SPO11 CC and CT genotypes were 87.5% (189/216) and 12.5% (27/216) in the patients, and 97.5% (193/198) and 2.5% (5/198) in the controls, respectively. The frequencies of SPO11 CC and CT genotypes, the A>G transition at nucleotide 313 in the exon 5 of the GSTP1 gene, and the frequencies of combined genotypes GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and SPO11 (CT) were significantly different between the two groups (P<0.05). CONCLUSION: The rs28368082 polymorphism of the SPO11 gene, the A>G transition at nucleotide 313 in the exon 5 of the GSTP1 gene, and the combined genotypes of GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and SPO11 (CT) may be associated with idiopathic male infertility in ethnic Han Chinese.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Predisposição Genética para Doença / Endodesoxirribonucleases / Glutationa S-Transferase pi / Glutationa Transferase / Infertilidade Masculina Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Humans / Male País/Região como assunto: Asia Idioma: Zh Revista: Zhonghua Yi Xue Yi Chuan Xue Za Zhi Assunto da revista: GENETICA MEDICA Ano de publicação: 2015 Tipo de documento: Article País de publicação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Predisposição Genética para Doença / Endodesoxirribonucleases / Glutationa S-Transferase pi / Glutationa Transferase / Infertilidade Masculina Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Humans / Male País/Região como assunto: Asia Idioma: Zh Revista: Zhonghua Yi Xue Yi Chuan Xue Za Zhi Assunto da revista: GENETICA MEDICA Ano de publicação: 2015 Tipo de documento: Article País de publicação: China