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Identification of new pyrrole alkaloids from the fruits of Lycium chinense.
Youn, Ui Joung; Lee, Joo Yun; Kil, Yun-Seo; Han, Ah-Reum; Chae, Chong Hak; Ryu, Shi Yong; Seo, Eun-Kyoung.
Afiliação
  • Youn UJ; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.
  • Lee JY; Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
  • Kil YS; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.
  • Han AR; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.
  • Chae CH; Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
  • Ryu SY; Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
  • Seo EK; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea. yuny@ewha.ac.kr.
Arch Pharm Res ; 39(3): 321-7, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26678273
Three new minor pyrrole alkaloids, 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1-methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate (3) were isolated from the fruits of Lycium chinense Miller (Solanaceae), along with the known compound, methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate (4). The structures of 1-4 were elucidated by analysis of their 1D- and 2D-NMR and HRMS data. The absolute configurations of 2-4, possessing a stereogenic center in each structure, were determined by comparison of their experimental electronic circular dichroism (ECD) with those of calculated ECD values.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirróis / Lycium / Alcaloides Tipo de estudo: Diagnostic_studies Idioma: En Revista: Arch Pharm Res Ano de publicação: 2016 Tipo de documento: Article País de publicação: Coréia do Sul

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirróis / Lycium / Alcaloides Tipo de estudo: Diagnostic_studies Idioma: En Revista: Arch Pharm Res Ano de publicação: 2016 Tipo de documento: Article País de publicação: Coréia do Sul