Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains.

Kim, Jin Hyang; Liepkalns, Justine; Reber, Adrian J; Lu, Xiuhua; Music, Nedzad; Jacob, Joshy; Sambhara, Suryaprakash

Kim, Jin Hyang; Liepkalns, Justine; Reber, Adrian J; Lu, Xiuhua; Music, Nedzad; Jacob, Joshy; Sambhara, Suryaprakash.

Afiliação

Kim JH; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.
Liepkalns J; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.
Reber AJ; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.
Lu X; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.
Music N; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.
Jacob J; Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, 954 Gatewood Rd, Atlanta, GA 30329, USA. Electronic address: joshy.jacob@emory.edu.
Sambhara S; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA. Electronic address: zao1@cdc.gov.

Vaccine ; 34(4): 495-502, 2016 Jan 20.

Article em En | MEDLINE | ID: mdl-26706277

Assuntos

Variação Antigênica; Reações Cruzadas; Vacinas contra Influenza/imunologia; Infecções por Orthomyxoviridae/imunologia; Animais; Anticorpos Antivirais/imunologia; Relação Dose-Resposta Imunológica; Memória Imunológica; Vírus da Influenza A Subtipo H1N1; Vacinas contra Influenza/administração & dosagem; Camundongos; Camundongos Endogâmicos BALB C; Testes de Neutralização; Infecções por Orthomyxoviridae/prevenção & controle; Vacinação

Palavras-chave

Antigenic drift; Infection; Influenza virus; Pandemic H1N1; Vaccine efficacy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Antigênica / Vacinas contra Influenza / Infecções por Orthomyxoviridae / Reações Cruzadas Limite: Animals Idioma: En Revista: Vaccine Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Holanda

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