Antityphoid properties and toxicity evaluation of Harungana madagascariensis Lam (Hypericaceae) aqueous leaf extract.
J Ethnopharmacol
; 179: 137-45, 2016 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-26721224
ABSTRACT
CONTEXT Harungana madagascariensis Lam is commonly used in Cameroonian folk medicine for the treatment of malaria and typhoid fever. OBJECTIVE:
To investigate the therapeutic potentials of H. madagascariensis aqueous leaf extract for the treatment of salmonellosis (e.g. typhoid fever, gastroenteritis). MATERIALS ANDMETHODS:
A Salmonella Typhimurium-infected rat model was used. The faeces of these rats were analysed for viable Salmonella Typhimurium before and after infection, and during the treatment period. The physiological, biochemical and histopathological markers of possible side effects of the extract were also studied using standard methods and kits. RESULTS ANDDISCUSSION:
The in vivo antisalmonellal study revealed that this extract significantly (P<0.05) reduced the number of viable Salmonella Typhimurium recovered from faeces, and could stop salmonellosis after 10 days of treatment for male and female rats, with non-toxic doses. However, the biochemical and histological analyses revealed that at relatively high-doses (≥100mg/kg for females and 200mg/kg for males) the extract could induce liver damage, as illustrated by a rise of serum transaminases (ALT and AST), significant inflammation of the parenchyma and portal vein, as well as cell necrosis. There were also increases in cholesterol levels in both sexes. No significant unwanted side effect of the extract was observed on the kidney, as shown by both serum and urinary creatinine, and urinary protein levels.CONCLUSION:
The results obtained showed that H. madagascariensis has a promising antisalmonellal effect and, therefore, the potential to provide an effective treatment against salmonellosis, including typhoid fever.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Febre Tifoide
/
Extratos Vegetais
/
Clusiaceae
/
Antibacterianos
Limite:
Animals
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Camarões