Association Between Vitamin D Receptor Polymorphism and Familial Mediterranean Fever Disease in Turkish Children.
Biochem Genet
; 54(2): 169-76, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26742922
ABSTRACT
Familial Mediterranean fever (FMF) is an autosomal recessive, inherited autoinflammatory disease characterized by recurrent, self-limited attacks of fever, and inflammation of serosal surfaces. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of children with FMF. We investigated VDR FokI (rs10735810), TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232) polymorphisms in 50 children with FMF and 150 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism. There was no significant difference between patients and controls for VDR FokI, TaqI, BsmI, and ApaI genotypes and alleles (p > 0.05). Results need to be supported by further investigations that define haplotype patterns for VDR gene polymorphisms in a larger group and different ethnic groups of FMF patients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Febre Familiar do Mediterrâneo
/
Polimorfismo de Fragmento de Restrição
/
Receptores de Calcitriol
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Biochem Genet
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Turquia