Design of chimeric antigen receptors with integrated controllable transient functions.
Sci Rep
; 6: 18950, 2016 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-26750734
ABSTRACT
The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new CAR architecture with an integrated switch-on system that permits to control the CAR T-cell function. This system offers the advantage of a transient CAR T-cell for safety while letting open the possibility of multiple cytotoxicity cycles using a small molecule drug.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Engenharia Genética
/
Citotoxicidade Imunológica
/
Proteínas Mutantes Quiméricas
Limite:
Humans
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos