Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease.

Wilson, Edward N; Abela, Andrew R; Do Carmo, Sonia; Allard, Simon; Marks, Adam R; Welikovitch, Lindsay A; Ducatenzeiler, Adriana; Chudasama, Yogita; Cuello, A Claudio

Wilson, Edward N; Abela, Andrew R; Do Carmo, Sonia; Allard, Simon; Marks, Adam R; Welikovitch, Lindsay A; Ducatenzeiler, Adriana; Chudasama, Yogita; Cuello, A Claudio.

Afiliação

Wilson EN; Department of Pharmacology and Therapeutics, McGill University, Montreal, QCCanadaH3G 1Y6.
Abela AR; Department of Psychology, McGill University, Montreal, QCCanadaH3A 1B1.
Do Carmo S; Department of Pharmacology and Therapeutics, McGill University, Montreal, QCCanadaH3G 1Y6.
Allard S; Department of Pharmacology and Therapeutics, McGill University, Montreal, QCCanadaH3G 1Y6.
Marks AR; Department of Pharmacology and Therapeutics, McGill University, Montreal, QCCanadaH3G 1Y6.
Welikovitch LA; Department of Pharmacology and Therapeutics, McGill University, Montreal, QCCanadaH3G 1Y6.
Ducatenzeiler A; Department of Pharmacology and Therapeutics, McGill University, Montreal, QCCanadaH3G 1Y6.
Chudasama Y; Department of Psychology, McGill University, Montreal, QC Canada H3A 1B1.
Cuello AC; Current address: National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.

Cereb Cortex ; 27(2): 1501-1511, 2017 02 01.

Article em En | MEDLINE | ID: mdl-26759481

Assuntos

Doença de Alzheimer/genética; Peptídeos beta-Amiloides/metabolismo; Cognição/fisiologia; Hipocampo/metabolismo; Plasticidade Neuronal/genética; Fatores de Transcrição/genética; Doença de Alzheimer/patologia; Precursor de Proteína beta-Amiloide/genética; Animais; Modelos Animais de Doenças; Feminino; Interneurônios/metabolismo; Masculino; Neurônios/metabolismo; Ratos Transgênicos

Palavras-chave

Alzheimer disease; CRTC1; amyloid beta; learning and memory; touchscreen operant platform

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Peptídeos beta-Amiloides / Cognição / Doença de Alzheimer / Hipocampo / Plasticidade Neuronal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cereb Cortex Assunto da revista: CEREBRO Ano de publicação: 2017 Tipo de documento: Article

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