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Involvement of F-box proteins in esophageal cancer (Review).
Gong, Jian; Huang, Zheng; Huo, Ji-Rong.
Afiliação
  • Gong J; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
  • Huang Z; Department of Spine Surgery, Shenzhen Nanshan Hospital of Guangdong Medical College, Shenzhen, Guangdong 510282, P.R. China.
  • Huo JR; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Int J Oncol ; 48(3): 886-94, 2016 Mar.
Article em En | MEDLINE | ID: mdl-26782762
ABSTRACT
The F-box proteins (FBPs) in esophageal tumorigenesis are pivotal as they govern a broad array of basic physiological responses including cell growth, cell death and DNA damage repair. Esophageal cancer (EC) is a common and highly aggressive cancer worldwide. Aberrant stabilization of crucial proteins participates in esophageal tumorigenesis. Recently, growing evidence has shown that FBPs play a critical role in oncogenesis, invasion, metastasis and prognosis assessment of EC. In this review we summarized published data on the roles of known FBPs, their respective substrates and the key signaling pathways, in the development of EC, aiming to uncover new ways for the rational design of targeted therapies in EC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Regulação Neoplásica da Expressão Gênica / Proteínas F-Box Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Regulação Neoplásica da Expressão Gênica / Proteínas F-Box Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article