Atrazine and its main metabolites alter the locomotor activity of larval zebrafish (Danio rerio).
Chemosphere
; 148: 163-70, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26803580
Atrazine (ATZ) and its main chlorometabolites, i.e., diaminochlorotriazine (DACT), deisopropylatrazine (DIP), and deethylatrazine (DE), have been widely detected in aquatic systems near agricultural fields. However, their possible effects on aquatic animals are still not fully understood. In this study, it was observed that several developmental endpoints such as the heart beat, hatchability, and morphological abnormalities were influenced by ATZ and its metabolites in different developmental stages. In addition, after 5 days of exposure to 30, 100, 300 µg L(-1) ATZ and its main chlorometabolites, the swimming behaviors of larval zebrafish were significantly disturbed, and the acetylcholinesterase (AChE) activities were consistently inhibited. Our results also demonstrate that ATZ and its main chlorometabolites are neuroendocrine disruptors that impact the expression of neurotoxicity-related genes such as Ache, Gap43, Gfap, Syn2a, Shha, Mbp, Elavl3, Nestin and Ngn1 in early developmental stages of zebrafish. According to our results, it is possible that not only ATZ but also its metabolites (DACT, DIP and DE) have the same or even more toxic effects on different endpoints of the early developmental stages of zebrafish.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atrazina
/
Triazinas
/
Poluentes Químicos da Água
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Peixe-Zebra
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Embrião não Mamífero
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Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Chemosphere
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Reino Unido