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Higher urine heat shock protein 70/creatinine ratio in type 1 diabetes mellitus.
Yilmaz, Alev; Gedikbasi, Asuman; Yuruk Yildirim, Zeynep; Pehlivanoglu, Cemile; Seker, Basak; Sucu, Aysegul; Bundak, Ruveyde; Emre, Sevinc.
Afiliação
  • Yilmaz A; a Pediatric Nephrology Department, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey ;
  • Gedikbasi A; b Biochemistry Department , Bakirkoy Dr. Sadi Konuk Training and Research Hospital , Istanbul , Turkey ;
  • Yuruk Yildirim Z; a Pediatric Nephrology Department, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey ;
  • Pehlivanoglu C; a Pediatric Nephrology Department, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey ;
  • Seker B; c Pediatrics Department, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey ;
  • Sucu A; a Pediatric Nephrology Department, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey ;
  • Bundak R; d Pediatric Endocrinology Department, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey.
  • Emre S; a Pediatric Nephrology Department, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey ;
Ren Fail ; 38(3): 404-10, 2016.
Article em En | MEDLINE | ID: mdl-26820050
ABSTRACT
Insidious progressive renal damage caused by type 1 diabetes mellitus (T1DM) begins in childhood before it becomes manifest in adult ages. Heat shock proteins (HSPs) regulate the cell response to any hazardous factors to prevent cell structure. The aim of the study is to determine whether urine levels of HSPs increase in diabetic children with time and indicate a progressive renal injury in T1DM. Thirty-three patients with T1DM and 24 healthy children were enrolled in the study. Renal function was normal in all patients. Urine levels of HSP27, HSP40, HSP60, HSP70, and HSP90 were measured by enzyme-linked immunosorbent assay at two consecutive years (2012 and 2013). The results were evaluated as urine HSP/creatinine ratios (uHSP/Cr). Mean urine HSP27/Cr, HSP40/Cr, HSP60/Cr, HSP70/Cr, HSP90/Cr in patient group were significantly higher than in controls in 2012 (uHSP27/Cr 460.12 ± 217.64 versus 270.02 ± 136.83 pg/mgCr; uHSP40/Cr 180.89 ± 118.59 versus 99.44 ± 62.49 pg/mgCr; uHSP60/Cr 114.40 ± 64.91 versus 70.50 ± 43.70 pg/mgCr; uHSP70/Cr 41.17 ± 28.42 versus 16.47 ± 7.32 pg/mgCr; uHSP90/Cr 175.64 ± 102.22 versus 107.61 ± 75.85 pg/mgCr) (p < 0.05). In 2013, uHSP70/Cr level increased significantly (51.08 ± 27.72 pg/mgCr; p = 0.001), whereas uHSP60/Cr level decreased and uHSP27/Cr, uHSP40/Cr, uHSP90/Cr levels remained stable (p > 0.05). Area under the curve (AUC) for uHSP70/Cr (0.957) was significantly higher than the others. Using a cutoff 22.59 pg/mgCr for uHSP70/Cr to predict of diabetic damage, sensitivity and specificity were 85% and 96%, respectively. Our results suggest that uHSP70/Cr increases over time and may indicate early phases of progressive kidney damage in diabetic children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP70 / Creatinina / Diabetes Mellitus Tipo 1 / Nefropatias Diabéticas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Ren Fail Assunto da revista: NEFROLOGIA Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Choque Térmico HSP70 / Creatinina / Diabetes Mellitus Tipo 1 / Nefropatias Diabéticas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Ren Fail Assunto da revista: NEFROLOGIA Ano de publicação: 2016 Tipo de documento: Article