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Vascularized composite allotransplantation: a closer look at the banff working classification.
Schneider, Michelle; Cardones, Adela Rambi G; Selim, M Angelica; Cendales, Linda C.
Afiliação
  • Schneider M; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
  • Cardones AR; Dermatology, Duke University Medical Center, Durham, NC, USA.
  • Selim MA; Pathology and Dermatology, Department of Pathology, Duke University Medical Center, Durham, NC, USA.
  • Cendales LC; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Transpl Int ; 29(6): 663-71, 2016 Jun.
Article em En | MEDLINE | ID: mdl-26841362
ABSTRACT
The first Banff vascularized composite allotransplantation meeting was held in 2007 to standardize criteria for the characterization and reporting of severity and types of rejection. As a result, the 2007 Banff VCA working classification for skin allograft pathology was formalized and now serves as the standard for diagnosis of VCA rejection. Similar to other working classification systems, strengths and limitations have been identified including the adequacy of the specimen, the definition of severity between grades, the reproducibility, the adequacy of the specimens, the types of rejection, and the integration of newer technologies such as molecular and genomic approaches. Although a relatively few number of cases have been performed and followed up to date, additional phenotypes such as antibody-mediated rejection, fibrosis, atrophy, and vascular changes are being reported and characterized based on accumulated experience in the field of VCA and parallels with other solid organs. This study aims to consider strengths and limitations of the Banff VCA working system and highlights ongoing challenges and opportunities available related to histopathology in this emerging field of transplantation.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alotransplante de Tecidos Compostos Vascularizados / Rejeição de Enxerto / Anticorpos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Transpl Int Assunto da revista: TRANSPLANTE Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alotransplante de Tecidos Compostos Vascularizados / Rejeição de Enxerto / Anticorpos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Transpl Int Assunto da revista: TRANSPLANTE Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos