Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.
J Antibiot (Tokyo)
; 42(11): 1673-83, 1989 Nov.
Article
em En
| MEDLINE
| ID: mdl-2684947
ABSTRACT
Reductive amination of the C-20 aldehyde group of tylosin and related macrolides yielded a large series of derivatives with potentially useful antibiotic properties. Evaluation of these new compounds was conducted on the basis of 1) Broad antimicrobial spectrum in vitro, with particular emphasis on inhibition of Pasteurella multocida and Pasteurella haemolytica; 2) in vivo efficacy, especially when given orally, against P. multocida in experimental infections in chicks; and 3) bioavailability after oral administration to laboratory animals. The most useful activity was found within a series of derivatives produced by reductive amination of desmycosin with secondary amines.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tilosina
/
Pasteurella
Limite:
Animals
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1989
Tipo de documento:
Article