Colonoscopic screening shows increased early incidence and progression of adenomas in cystic fibrosis.
J Cyst Fibros
; 15(4): 548-53, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-26851188
ABSTRACT
BACKGROUND:
Colorectal cancer is an emerging problem in cystic fibrosis (CF). The goal of this study was to evaluate adenoma detection by systematic colonoscopic screening and surveillance.METHODS:
We analyzed prospectively collected results of colonoscopies initiated at age 40years from 88 CF patients at a single Cystic Fibrosis Center. We also reviewed results of diagnostic colonoscopies from 27 patients aged 30-39years performed during the same time period at the Center.RESULTS:
The incidence of polyp detection increased markedly after age 40 in CF patients. Greater than 50% were found to have adenomatous polyps; approximately 25% had advanced adenomas as defined by size and/or histopathology; 3% were found to have colon cancer. Multivariate analysis demonstrated specific risk factors for adenoma formation and progression.CONCLUSIONS:
Early screening and more frequent surveillance should be considered in patients with CF due to early incidence and progression of adenomas in this patient population.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Adenoma
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Colonoscopia
/
Fibrose Cística
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
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Female
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Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Cyst Fibros
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos