N-Acetylgalactosamine Block-co-Polycations Form Stable Polyplexes with Plasmids and Promote Liver-Targeted Delivery.

Dhande, Yogesh K; Wagh, Bharat S; Hall, Bryan C; Sprouse, Dustin; Hackett, Perry B; Reineke, Theresa M

Dhande, Yogesh K; Wagh, Bharat S; Hall, Bryan C; Sprouse, Dustin; Hackett, Perry B; Reineke, Theresa M.

Afiliação

Dhande YK; Department of Chemical Engineering and Materials Science, and Center for Genome Engineering, Department of Chemistry and Center for Genome Engineering, and §Department of Genetics, Cell Biology and Development, and Center for Genome Engineering, University of Minnesota , Minneapolis, Minnesota 5545
Wagh BS; Department of Chemical Engineering and Materials Science, and Center for Genome Engineering, Department of Chemistry and Center for Genome Engineering, and §Department of Genetics, Cell Biology and Development, and Center for Genome Engineering, University of Minnesota , Minneapolis, Minnesota 5545
Hall BC; Department of Chemical Engineering and Materials Science, and Center for Genome Engineering, Department of Chemistry and Center for Genome Engineering, and §Department of Genetics, Cell Biology and Development, and Center for Genome Engineering, University of Minnesota , Minneapolis, Minnesota 5545
Sprouse D; Department of Chemical Engineering and Materials Science, and Center for Genome Engineering, Department of Chemistry and Center for Genome Engineering, and §Department of Genetics, Cell Biology and Development, and Center for Genome Engineering, University of Minnesota , Minneapolis, Minnesota 5545
Hackett PB; Department of Chemical Engineering and Materials Science, and Center for Genome Engineering, Department of Chemistry and Center for Genome Engineering, and §Department of Genetics, Cell Biology and Development, and Center for Genome Engineering, University of Minnesota , Minneapolis, Minnesota 5545
Reineke TM; Department of Chemical Engineering and Materials Science, and Center for Genome Engineering, Department of Chemistry and Center for Genome Engineering, and §Department of Genetics, Cell Biology and Development, and Center for Genome Engineering, University of Minnesota , Minneapolis, Minnesota 5545

Biomacromolecules ; 17(3): 830-40, 2016 Mar 14.

Article em En | MEDLINE | ID: mdl-26854615

Assuntos

Acetilgalactosamina/química; Portadores de Fármacos/química; Fígado/metabolismo; Plasmídeos/administração & dosagem; Poliaminas/química; Animais; Receptor de Asialoglicoproteína/genética; Receptor de Asialoglicoproteína/metabolismo; DNA/administração & dosagem; Portadores de Fármacos/efeitos adversos; Portadores de Fármacos/síntese química; Etilaminas/química; Terapia Genética/métodos; Células HeLa; Células Hep G2; Hepatócitos/efeitos dos fármacos; Hepatócitos/metabolismo; Humanos; Fígado/efeitos dos fármacos; Metacrilatos/química; Camundongos; Camundongos Endogâmicos C57BL; Polieletrólitos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmídeos / Poliaminas / Acetilgalactosamina / Portadores de Fármacos / Fígado Limite: Animals / Humans Idioma: En Revista: Biomacromolecules Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2016 Tipo de documento: Article

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