Could we offer mitochondrial donation or similar assisted reproductive technology to South African patients with mitochondrial DNA disease?
S Afr Med J
; 106(3): 234-6, 2016 Feb 02.
Article
em En
| MEDLINE
| ID: mdl-26915934
ABSTRACT
The decision of the UK House of Commons in 2015 to endorse the use of pioneering in vitro fertilisation techniques to protect future generations from the risk of mitochondrial DNA (mtDNA) disease has sparked worldwide controversy and debate. The availability of such technologies could benefit women at risk of transmitting deleterious mutations. MtDNA disease certainly occurs in South Africa (SA) in all population groups. However, diagnostic strategies and practices for identifying individuals who would benefit from technologies such as IVF have in the past been suboptimal in this country. New developments in the molecular diagnostic services available to SA patients, as well as better education of referring clinicians and the implementation of more structured, population-appropriate diagnostic strategies, may open the floor to this debate in SA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
/
Doenças Mitocondriais
/
Técnicas de Reprodução Assistida
/
Terapia de Substituição Mitocondrial
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
S Afr Med J
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
África do Sul