The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity.
Oncoimmunology
; 5(1): e1064579, 2016.
Article
em En
| MEDLINE
| ID: mdl-26942081
ABSTRACT
Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Oncoimmunology
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Argentina