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Vectorization of Nucleic Acids for Therapeutic Approach: Tutorial Review.
Geinguenaud, Frederic; Guenin, Erwann; Lalatonne, Yoann; Motte, Laurence.
Afiliação
  • Geinguenaud F; Laboratoire CSPBAT, CNRS UMR 7244, UFR SMBH, Université Paris 13 , Sorbonne Paris Cité, F-93017 Bobigny, France.
  • Guenin E; Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13 , Sorbonne Paris Cité, F-93017 Bobigny, France.
  • Lalatonne Y; Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13 , Sorbonne Paris Cité, F-93017 Bobigny, France.
  • Motte L; Service de Médecine Nucléaire, Hôpital Avicenne Assistance Publique-Hôpitaux de Paris 93009 Bobigny France.
ACS Chem Biol ; 11(5): 1180-91, 2016 05 20.
Article em En | MEDLINE | ID: mdl-26950048
Oligonucleotides present a high therapeutic potential for a wide variety of diseases. However, their clinical development is limited by their degradation by nucleases and their poor blood circulation time. Depending on the administration mode and the cellular target, these macromolecules will have to cross the vascular endothelium, to diffuse through the extracellular matrix, to be transported through the cell membrane, and finally to reach the cytoplasm. To overcome these physiological barriers, many strategies have been developed. Here, we review different methods of DNA vectorization, discuss limitations and advantages of the various vectors, and provide new perspectives for future development.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Ácidos Nucleicos / Sistemas de Liberação de Medicamentos / Técnicas de Transferência de Genes Limite: Animals / Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Ácidos Nucleicos / Sistemas de Liberação de Medicamentos / Técnicas de Transferência de Genes Limite: Animals / Humans Idioma: En Revista: ACS Chem Biol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos