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A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension.
Mohamed, Nura A; Ahmetaj-Shala, Blerina; Duluc, Lucie; Mackenzie, Louise S; Kirkby, Nicholas S; Reed, Daniel M; Lickiss, Paul D; Davies, Robert P; Freeman, Gemma R; Wojciak-Stothard, Beata; Chester, Adrian H; El-Sherbiny, Ibrahim M; Mitchell, Jane A; Yacoub, Magdi H.
Afiliação
  • Mohamed NA; Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK.
  • Ahmetaj-Shala B; Heart Science Centre, Imperial College, Harefield, Uxbridge, UB9 6JH, UK.
  • Duluc L; Qatar Foundation Research and Development Division, Doha, Qatar.
  • Mackenzie LS; Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK.
  • Kirkby NS; Department of Experimental Medicine and Toxicology, Hammersmith Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK.
  • Reed DM; School of Life and Medical Sciences, University of Hertfordshire, Hatfield, AL10 9AB, UK.
  • Lickiss PD; Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK.
  • Davies RP; Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK.
  • Freeman GR; Synthesis Section, Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
  • Wojciak-Stothard B; Synthesis Section, Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
  • Chester AH; Synthesis Section, Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK.
  • El-Sherbiny IM; Department of Experimental Medicine and Toxicology, Hammersmith Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK.
  • Mitchell JA; Heart Science Centre, Imperial College, Harefield, Uxbridge, UB9 6JH, UK.
  • Yacoub MH; Center for Materials Science, Zewail City, Sheikh, Zayed District, 12588, 6th of October City, Giza, Egypt.
J Cardiovasc Transl Res ; 9(2): 162-4, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26960567
Pulmonary arterial hypertension (PAH) is a chronic and progressive disease which continues to carry an unacceptably high mortality and morbidity. The nitric oxide (NO) pathway has been implicated in the pathophysiology and progression of the disease. Its extremely short half-life and systemic effects have hampered the clinical use of NO in PAH. In an attempt to circumvent these major limitations, we have developed a new NO-nanomedicine formulation. The formulation was based on hydrogel-like polymeric composite NO-releasing nanoparticles (NO-RP). The kinetics of NO release from the NO-RP showed a peak at about 120 min followed by a sustained release for over 8 h. The NO-RP did not affect the viability or inflammation responses of endothelial cells. The NO-RP produced concentration-dependent relaxations of pulmonary arteries in mice with PAH induced by hypoxia. In conclusion, NO-RP drugs could considerably enhance the therapeutic potential of NO therapy for PAH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artéria Pulmonar / Doadores de Óxido Nítrico / Nanopartículas / Pressão Arterial / Hipertensão Pulmonar / Anti-Hipertensivos / Óxido Nítrico Limite: Animals Idioma: En Revista: J Cardiovasc Transl Res Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artéria Pulmonar / Doadores de Óxido Nítrico / Nanopartículas / Pressão Arterial / Hipertensão Pulmonar / Anti-Hipertensivos / Óxido Nítrico Limite: Animals Idioma: En Revista: J Cardiovasc Transl Res Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos