A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement.
Biomaterials
; 88: 110-9, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26976264
ABSTRACT
Nucleus pulposus replacements have been subjected to highly controversial discussions over the last 40 years. Their use has not yet resulted in a positive outcome to treat herniated disc or degenerated disc disease. The main reason is that not a single implant or tissue replacement was able to withstand the loads within an intervertebral disc. Here, we report on the development of a photo-polymerizable poly(ethylene glycol)dimethacrylate nano-fibrillated cellulose composite hydrogel which was tuned according to native tissue properties. Using a customized minimally-invasive medical device to inject and photopolymerize the hydrogel insitu, samples were implanted through an incision of 1 mm into an intervertebral disc of a bovine organ model to evaluate their long-term performance. When implanted into the bovine disc model, the composite hydrogel implant was able to significantly re-establish disc height after surgery (p < 0.0025). The height was maintained after 0.5 million loading cycles (p < 0.025). The mechanical resistance of the novel composite hydrogel material combined with the minimally invasive implantation procedure into a bovine disc resulted in a promising functional orthopedic implant for the replacement of the nucleus pulposus.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
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Materiais Biocompatíveis
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Celulose
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Hidrogel de Polietilenoglicol-Dimetacrilato
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Degeneração do Disco Intervertebral
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Núcleo Pulposo
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Disco Intervertebral
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Metacrilatos
Limite:
Animals
Idioma:
En
Revista:
Biomaterials
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
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