[PARTICIPATION OF NO-ERGIC MECHANISMS IN REALIZATION OF RESPIRATORY EFFECTS OF PRO-INFLAMMATORY CYTOKINE INTERLEUKIN-1-BETA].
Ross Fiziol Zh Im I M Sechenova
; 101(12): 1372-84, 2015 Dec.
Article
em Ru
| MEDLINE
| ID: mdl-26987229
ABSTRACT
The role of NO-ergic mechanisms in the realization of the respiratory effects of pro-inflammatory cytokine IL-1beta was investigated in acute experiments on anesthetized rats. To achieve this, we studied the effect of intravenous administration of IL-1beta during inhibition of NO-synthase by N-nitro-L-arginine methyl ester (L-NAME, a non-specific blocker of NO-synthase) on the parameters of breathing and the Hering-Breuer inspiratory-inhibitory reflex. It was shown that the effect of L-NAME eliminates the IL-1beta-dependent increase of the Hering-Breuer reflex, whereas effects on breathing pattern does not change the increase in IL-1beta system-level evokes an increase in respiratory rate, tidal volume and lung ventilation. It is assumed that one of the mechanisms of enhance in the strength inspiratory-inhibitory reflex by increasing circulatory IL-1beta level is the increased glutamate-ergic transmission on pump-neurons induced by increase in nitric oxide synthesis in cerebrovascular endothelial cells. In conclusion, NO-ergic mechanisms participate in the modulation of the vagal respiratory reflexes during the development of the acute phase of systemic inflammation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reflexo
/
Respiração
/
Interleucina-1beta
/
Neurônios
/
Óxido Nítrico
Limite:
Animals
Idioma:
Ru
Revista:
Ross Fiziol Zh Im I M Sechenova
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article