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New insights into the endophenotypic status of cognition in bipolar disorder: genetic modelling study of twins and siblings.
Georgiades, Anna; Rijsdijk, Fruhling; Kane, Fergus; Rebollo-Mesa, Irene; Kalidindi, Sridevi; Schulze, Katja K; Stahl, Daniel; Walshe, Muriel; Sahakian, Barbara J; McDonald, Colm; Hall, Mei-Hua; Murray, Robin M; Kravariti, Eugenia.
Afiliação
  • Georgiades A; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Rijsdijk F; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Kane F; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Rebollo-Mesa I; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Kalidindi S; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Schulze KK; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Stahl D; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Walshe M; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Sahakian BJ; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • McDonald C; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Hall MH; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Murray RM; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
  • Kravariti E; Anna Georgiades, PhD, Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Fruhling Rijsdijk, PhD, MRC Social, Genetic and Develo
Br J Psychiatry ; 208(6): 539-47, 2016 06.
Article em En | MEDLINE | ID: mdl-26989096
ABSTRACT

BACKGROUND:

Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder.

AIMS:

To quantify the shared genetic variability between bipolar disorder and cognitive measures.

METHOD:

Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder.

RESULTS:

Using a parsimonious AE model, verbal episodic and spatial working memory showed statistically significant genetic correlations with bipolar disorder (rg = |0.23|-|0.27|), which lost statistical significance after covarying for affective symptoms. Using an ACE model, IQ and visual-spatial learning showed statistically significant genetic correlations with bipolar disorder (rg = |0.51|-|1.00|), which remained significant after covarying for affective symptoms.

CONCLUSIONS:

Verbal episodic and spatial working memory capture a modest fraction of the bipolar diathesis. IQ and visual-spatial learning may tap into genetic substrates of non-affective symptomatology in bipolar disorder.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Endofenótipos / Memória Episódica / Disfunção Cognitiva / Transtornos da Memória / Modelos Genéticos Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Psychiatry Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Endofenótipos / Memória Episódica / Disfunção Cognitiva / Transtornos da Memória / Modelos Genéticos Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Psychiatry Ano de publicação: 2016 Tipo de documento: Article