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Comparison of pathogenicities of H7 avian influenza viruses via intranasal and conjunctival inoculation in cynomolgus macaques.
Shichinohe, Shintaro; Itoh, Yasushi; Nakayama, Misako; Ozaki, Hiroichi; Soda, Kosuke; Ishigaki, Hirohito; Okamatsu, Masatoshi; Sakoda, Yoshihiro; Kida, Hiroshi; Ogasawara, Kazumasa.
Afiliação
  • Shichinohe S; Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
  • Itoh Y; Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
  • Nakayama M; Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
  • Ozaki H; Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan; Laboratory of Veterinary Microbiology, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
  • Soda K; Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan; Laboratory of Veterinary Infectious Diseases, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
  • Ishigaki H; Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
  • Okamatsu M; Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan.
  • Sakoda Y; Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Hokkaid
  • Kida H; Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Hokkaid
  • Ogasawara K; Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
Virology ; 493: 31-8, 2016 06.
Article em En | MEDLINE | ID: mdl-26994587
ABSTRACT
The outbreak of H7N9 low pathogenic avian influenza viruses in China has attracted attention to H7 influenza virus infection in humans. Since we have shown that the pathogenicity of H1N1 and H5N1 influenza viruses in macaques was almost the same as that in humans, we compared the pathogenicities of H7 avian influenza viruses in cynomolgus macaques via intranasal and conjunctival inoculation, which mimics natural infection in humans. H7N9 virus, as well as H7N7 highly pathogenic avian influenza virus, showed more efficient replication and higher pathogenicity in macaques than did H7N1 and H7N3 highly pathogenic avian influenza viruses. These results are different from pathogenicity in chickens as reported previously. Therefore, our results obtained in macaques help to estimate the pathogenicity of H7 avian influenza viruses in humans.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Orthomyxoviridae / Vírus da Influenza A Subtipo H7N1 / Vírus da Influenza A Subtipo H7N3 / Subtipo H7N9 do Vírus da Influenza A Limite: Animals / Female / Humans Idioma: En Revista: Virology Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Orthomyxoviridae / Vírus da Influenza A Subtipo H7N1 / Vírus da Influenza A Subtipo H7N3 / Subtipo H7N9 do Vírus da Influenza A Limite: Animals / Female / Humans Idioma: En Revista: Virology Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão