A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations.
J Occup Health
; 58(2): 196-200, 2016 May 25.
Article
em En
| MEDLINE
| ID: mdl-27010090
ABSTRACT
OBJECTIVES:
The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after seafood consumption. We estimated the urinary iAs+MMA concentration corresponding to iAs exposure.METHODS:
We used data from two arsenic speciation analyses of urine samples from 330 Bangladeshi with oral iAs exposure and 172 Japanese workers without occupational iAs exposure using high-performance liquid chromatography with inductively coupled plasma mass spectrometry.RESULTS:
iAs, MMA, and DMA, but not arsenobetaine (AsBe), were detected in the urine of the Bangladeshi subjects. The correlation between iAs+MMA+DMA and iAs+MMA was obtained as log (iAs+MMA) = 1.038 log (iAs+MMA+DMA) -0.658. Using the regression formula, the iAs+MMA value was calculated as 2.15 and 7.5 µg As/l, corresponding to 3 and 10 µg As/m(3) of exposures, respectively. In the urine of the Japanese workers, arsenic was mostly excreted as AsBe. We used the 95th percentile of iAs+MMA (12.6 µg As/l) as the background value. The sum of the calculated and background values can be used as a biological indicator of iAs exposure.CONCLUSION:
We propose 14.8 and 20.1 µg As/l of urinary iAs+MMA as the biological indicators of 3 and 10 µg As/m(3) iAs exposure, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arsênio
/
Arsenicais
/
Monitoramento Ambiental
/
Exposição Ocupacional
/
Exposição Ambiental
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Occup Health
Assunto da revista:
MEDICINA OCUPACIONAL
Ano de publicação:
2016
Tipo de documento:
Article