[Interaction of Arenicin-1 with C1q Protein].
Bioorg Khim
; 41(6): 664-8, 2015.
Article
em Ru
| MEDLINE
| ID: mdl-27125019
ABSTRACT
The interaction between arenicin-1, that is an antimicrobial peptide from polychaeta Arenicola marina, and human complement system protein C1q was studied using enzyme-linked receptor sorbent assay and ELISA. We revealed that arenicin-1 and C1q form complex that is stable in high ionic strength condition 0.5 M NaCl. The ability of C1q to interact with arenicin-1 is comparable with the binding activity of C1q towards another antimicrobial peptide, porcine cathelicidin protegrin-1, which has a similar spatial arrangement with arenicin-1. Namely, both arenicin-1 and protegrin-1 form cystine-stabilized antiparallel ß-hairpin structure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complemento C1q
/
Proteínas de Helminto
/
Peptídeos Catiônicos Antimicrobianos
Limite:
Animals
/
Humans
Idioma:
Ru
Revista:
Bioorg Khim
Ano de publicação:
2015
Tipo de documento:
Article