Adenosine analogs inhibit fighting in isolated male mice.
Life Sci
; 44(18): 1293-301, 1989.
Article
em En
| MEDLINE
| ID: mdl-2716472
ABSTRACT
The potent adenosine analogs N-ethylcarboxamide adenosine (NECA) and phenylisopropyladenosine (PIA) inhibit fighting and associated agonistic behaviors in isolated male mice. These effects are reversed by methylxanthines; moderate doses of NECA which inhibit fighting have minimal effects on spontaneous locomotor activity. At very low doses, both NECA and PIA increase fighting in parallel with previously reported increases of motor activity. Brain levels of [3H]-NECA and [3H]-PIA achieved at behaviorally effective doses suggest an involvement of adenosine receptors. The biochemical mechanism of adenosine receptor action with respect to fighting is unknown, but may include neuromodulatory effects on the release of other, more classical neurotransmitters.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilisopropiladenosina
/
Adenosina
/
Agressão
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Canadá