Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral &#954;-opioid receptor agonists.

Guo, Ting; Gan, Zongjie; Chen, Jie; Wang, Dechuan; He, Ling; Song, Qiao; Xu, Yungen

Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists.

Guo, Ting; Gan, Zongjie; Chen, Jie; Wang, Dechuan; He, Ling; Song, Qiao; Xu, Yungen.

Afiliação

Guo T; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Gan Z; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Chen J; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Wang D; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
He L; Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
Song Q; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Xu Y; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China. Electronic address: xu_yungen@hotmail.com.

Bioorg Med Chem ; 24(13): 2964-2970, 2016 07 01.

Article em En | MEDLINE | ID: mdl-27185012

Assuntos

Desenho de Fármacos; Dor/tratamento farmacológico; Receptores Opioides kappa/agonistas; Tetra-Hidroisoquinolinas/síntese química; Tetra-Hidroisoquinolinas/uso terapêutico; Ácido Acético; Analgésicos/síntese química; Analgésicos/química; Analgésicos/farmacologia; Animais; Hipnóticos e Sedativos/síntese química; Hipnóticos e Sedativos/química; Hipnóticos e Sedativos/farmacologia; Camundongos; Estrutura Molecular; Dor/induzido quimicamente; Ligação Proteica/efeitos dos fármacos; Tetra-Hidroisoquinolinas/química; Tetra-Hidroisoquinolinas/farmacologia

Palavras-chave

Peripheral; Tetrahydroisoquinoline quaternary derivatives; κ-Opioid receptor agonists

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Desenho de Fármacos / Receptores Opioides kappa / Tetra-Hidroisoquinolinas Limite: Animals Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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