[INDIVIDUAL EVALUATION OF LORETA ABNORMALITIES IN IDIOPATHIC GENERALIZED EPILEPSY]. / EGYEDI LORETA-ABNORMALITÁSOK VIZSGÁLATA IDIOPATHIÁS GENERALIZÁLT EPILEPSZIÁKBAN.
Ideggyogy Sz
; 69(3-4): 107-21, 2016 Mar 30.
Article
em Hu
| MEDLINE
| ID: mdl-27188003
ABSTRACT
BACKGROUND:
Contemporary neuroimaging methods disclosed structural and functional cerebral abnormalities in idiopathic generalized epilepsies (IGEs). However, individual electrical (EEG) abnormalities have not been evaluated yet in IGE patients.METHODS:
IGE patients were investigated in the drug-free condition and after 3-6 month of antiepileptic treatment. To estimate the reproducibility of qEEG variables a retrospective recruited cohort of IGE patients was investigated. 19-channel resting state EEG activity was recorded. For each patient a total of 2 minutes EEG activity was analyzed by LORETA (Low Resolution Electromagnetic Tomography). Raw LORETA values were Z-transformed and projected to a MRI template. Z-values outside within the [+3Z] to [-3Z] range were labelled as statistically abnormal.RESULTS:
1. In drug-free condition, 41-50% of IGE patients showed abnormal LORETA values. 2. Abnormal LORETA findings showed great inter-individual variability. 3. Most abnormal LORETA-findings were symmetrical. 4. Most maximum Z-values were localized to frontal or temporal cortex. 5. Succesfull treatment was mostly coupled with disappearence of LORETA-abnormality, persistent seizures were accompanied by persistent LORETA abnormality.DISCUSSION:
1. LORETA abnormalities detected in the untreated condition reflect seizure-generating property of the cortex in IGE patients. 2. Maximum LORETA-Z abnormalities were topographically congruent with structural abnormalities reported by other research groups. 3. LORETA might help to investigate drug effects at the whole-brain level.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tomografia
/
Córtex Cerebral
/
Epilepsia Generalizada
/
Fenômenos Eletromagnéticos
/
Neuroimagem
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Hu
Revista:
Ideggyogy Sz
Ano de publicação:
2016
Tipo de documento:
Article