Identification of polycystic ovary syndrome potential drug targets based on pathobiological similarity in the protein-protein interaction network.

Huang, Hao; He, Yuehan; Li, Wan; Wei, Wenqing; Li, Yiran; Xie, Ruiqiang; Guo, Shanshan; Wang, Yahui; Jiang, Jing; Chen, Binbin; Lv, Junjie; Zhang, Nana; Chen, Lina; He, Weiming

Huang, Hao; He, Yuehan; Li, Wan; Wei, Wenqing; Li, Yiran; Xie, Ruiqiang; Guo, Shanshan; Wang, Yahui; Jiang, Jing; Chen, Binbin; Lv, Junjie; Zhang, Nana; Chen, Lina; He, Weiming.

Afiliação

Huang H; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
He Y; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Li W; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Wei W; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Li Y; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Xie R; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Guo S; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Wang Y; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Jiang J; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Chen B; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Lv J; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Zhang N; Department of Endocrinology and Metabolism Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Chen L; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China.
He W; Institute of Opto-electronics, Harbin Institute of Technology, Harbin, Heilongjiang Province, China.

Oncotarget ; 7(25): 37906-37919, 2016 Jun 21.

Article em En | MEDLINE | ID: mdl-27191267

Assuntos

Diabetes Mellitus Tipo 2/metabolismo; Síndrome do Ovário Policístico/diagnóstico; Síndrome do Ovário Policístico/metabolismo; Mapas de Interação de Proteínas; Adulto; Simulação por Computador; Diabetes Mellitus Tipo 2/complicações; Desenho de Fármacos; Feminino; Humanos; Resistência à Insulina; Modelos Estatísticos; Síndrome do Ovário Policístico/tratamento farmacológico; Mapeamento de Interação de Proteínas; Curva ROC; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Máquina de Vetores de Suporte

Palavras-chave

drug target; module; pathobiological similarity; polycystic ovary syndrome; protein-protein interaction network

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Diabetes Mellitus Tipo 2 / Mapas de Interação de Proteínas Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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