Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
J Nat Prod
; 79(6): 1532-7, 2016 06 24.
Article
em En
| MEDLINE
| ID: mdl-27232656
ABSTRACT
A new para-aminobenzoic-acid-containing natural product from the mango pathogenic organism Xanthomonas citri pv. mangiferaeindicae is described. By means of stable isotope precursor feeding combined with nontargeted LC-MS/MS, the generated spectra were clustered and visualized in a molecular network. This led to the identification of a new member of the meroterpenoids, termed xanthomonic acid, which is composed of an isoprenylated para-aminobenzoic acid. In vitro cytotoxicity assays demonstrated activity of xanthomonic acid against several human cancer cell lines by induction of autophagy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças das Plantas
/
Terpenos
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Xanthomonas
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Ácido 4-Aminobenzoico
/
Mangifera
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Deutério
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Antineoplásicos
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha