Myelodysplastic Syndrome Occurring in a Patient with Gorlin Syndrome.
Pediatr Dermatol
; 33(4): e256-7, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27241746
ABSTRACT
We report a case of myelodysplastic syndrome (MDS) occurring in an African American boy with Gorlin syndrome with a novel PTCH1 mutation. Before developing MDS, the patient had been treated with chemotherapy and radiation for a medulloblastoma. He received a bone marrow transplant for the MDS and eventually died of treatment complications. Secondary hematologic malignancies are a known complication of certain chemotherapeutics, although whether a patient with Gorlin syndrome has a greater propensity for the development of such malignancies is unclear.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Mielodisplásicas
/
Síndrome do Nevo Basocelular
Limite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Dermatol
Ano de publicação:
2016
Tipo de documento:
Article