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Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.
Shatz, Whitney; Hass, Philip E; Mathieu, Mary; Kim, Hok Seon; Leach, Kim; Zhou, Michelle; Crawford, Yongping; Shen, Amy; Wang, Kathryn; Chang, Debby P; Maia, Mauricio; Crowell, Susan R; Dickmann, Leslie; Scheer, Justin M; Kelley, Robert F.
Afiliação
  • Shatz W; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Hass PE; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Mathieu M; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Kim HS; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Leach K; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhou M; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Crawford Y; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Shen A; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Wang K; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Chang DP; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Maia M; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Crowell SR; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Dickmann L; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Scheer JM; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
  • Kelley RF; Departments of Protein Chemistry, ‡Antibody Engineering, §Early Stage Cell Culture, ∥Bioanalytical Assay Services, ⊥Preclinical and Translational Pharmacokinetics, and #Drug Delivery, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Mol Pharm ; 13(9): 2996-3003, 2016 09 06.
Article em En | MEDLINE | ID: mdl-27244474
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos Fab das Imunoglobulinas / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos Fab das Imunoglobulinas / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos