Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
Glia
; 64(10): 1788-94, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27246804
ABSTRACT
Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted. GLIA 2016;641788-1794.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microglia
/
Minociclina
/
Antibacterianos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Glia
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article