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Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis - a clinical study.
Anuradha, Ardra; Patil, Bharati; Asha, Venkataswamy Reddy.
Afiliação
  • Anuradha A; Department of Oral medicine & radiology, The Oxford College and Hospital, Bangalore, India.
  • Patil B; Department of Oral medicine & radiology, The Oxford College and Hospital, Bangalore, India.
  • Asha VR; Department of Oral medicine & radiology, The Oxford College and Hospital, Bangalore, India.
J Oral Pathol Med ; 46(1): 50-55, 2017 Jan.
Article em En | MEDLINE | ID: mdl-27314762
BACKGROUND: Oral submucous fibrosis is a chronic disease, treatment of which has largely been symptomatic. Aloe vera has immunomodulatory, anti-inflammatory, wound healing, antioxidant, and antineoplastic activities. All such properties of aloe vera suggest the possibility of its use in the management of oral submucous fibrosis. METHODS: Seventy-four patients of oral submucous fibrosis were randomly divided into 2 groups. Group A patients were treated with systemic (juice) and topical aloe vera (gel) for 3 months. Group B patients were treated with intralesional injection of hydrocortisone and hyaluronidase for 6 weeks with antioxidant supplements for 3 months. Patients were assessed for reduction in burning sensation and increase in mouth opening, cheek flexibility, and tongue protrusion at an interval of 1, 2, and 3 months. RESULTS: Both the groups showed statistically significant improvements in all the study parameters at the end of study period (P < 0.001). The clinical response to aloe vera was comparable to that of intralesional injections of hydrocortisone and hyaluronidase with antioxidant supplementation. CONCLUSION: The study concludes that aloe vera can be an alternative, safe, and effective treatment regime in the management of oral submucous fibrosis. Long-term follow-up studies with larger sample size are recommended.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Oral Submucosa / Hidrocortisona / Aloe / Fitoterapia / Anti-Inflamatórios Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia País de publicação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Oral Submucosa / Hidrocortisona / Aloe / Fitoterapia / Anti-Inflamatórios Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia País de publicação: Dinamarca