Similar α-Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls.
Mov Disord
; 31(10): 1567-1570, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27324838
ABSTRACT
BACKGROUND:
The gut is proposed as a starting point of idiopathic IPD, but the presence of α-synuclein in the IPD colon mucosa is debated.OBJECTIVES:
The objective of this study was to evaluate if α-synuclein in the colon mucosa can serve as a biomarker of IPD.METHODS:
Immunohistochemistry was used to locate and quantify in a blinded approach α-synuclein in the mucosa from biopsies of the right and left colon in 19 IPD patients and 8 controls.RESULTS:
Total α-synuclein was present in all but 1 IPD patients and in all controls; phosphorylated α-synuclein was present in all subjects. There was no intensity difference depending on disease status. Staining of total α-synuclein was stronger in the right colon (p = .04).CONCLUSIONS:
Conventional immunohistochemistry α-synuclein staining in colon mucosal biopsies cannot serve as a biomarker of idiopathic PD. These findings do not contradict the assumption of disease starting in the colon, and a colon segment-specific risk for disease initiation can still be hypothesized. © 2016 International Parkinson and Movement Disorder Society.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Colo
/
Alfa-Sinucleína
/
Mucosa Intestinal
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mov Disord
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Luxemburgo