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Targeting Androgen Receptor Aberrations in Castration-Resistant Prostate Cancer.
Sharp, Adam; Welti, Jonathan; Blagg, Julian; de Bono, Johann S.
Afiliação
  • Sharp A; Prostate Cancer Targeted Therapy Group, Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.
  • Welti J; Prostate Cancer Targeted Therapy Group, Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.
  • Blagg J; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.
  • de Bono JS; Prostate Cancer Targeted Therapy Group, Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom. johann.de-bono@icr.ac.uk.
Clin Cancer Res ; 22(17): 4280-2, 2016 Sep 01.
Article em En | MEDLINE | ID: mdl-27330057
ABSTRACT
Androgen receptor (AR) splice variants (SV) have been implicated in the development of metastatic castration-resistant prostate cancer and resistance to AR targeting therapies, including abiraterone and enzalutamide. Agents targeting AR-SV are urgently needed to test this hypothesis and further improve the outcome of patients suffering from this lethal disease. Clin Cancer Res; 22(17); 4280-2. ©2016 AACRSee related article by Yang et al., p. 4466.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Androgênicos / Antagonistas de Receptores de Andrógenos / Terapia de Alvo Molecular / Neoplasias de Próstata Resistentes à Castração / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Androgênicos / Antagonistas de Receptores de Andrógenos / Terapia de Alvo Molecular / Neoplasias de Próstata Resistentes à Castração / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido