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Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders.
Sci Rep ; 6: 28636, 2016 06 27.
Artigo em Inglês | MEDLINE | ID: mdl-27346785
ABSTRACT
The secreted glycoprotein Reelin is believed to play critical roles in the pathogenesis of several neuropsychiatric disorders. The highly basic C-terminal region (CTR) of Reelin is necessary for efficient activation of its downstream signaling, and the brain structure of knock-in mice that lack the CTR (ΔC-KI mice) is impaired. Here, we performed a comprehensive behavioral test battery on ΔC-KI mice, in order to evaluate the effects of partial loss-of-function of Reelin on brain functions. The ΔC-KI mice were hyperactive and exhibited reduced anxiety-like and social behaviors. The working memory in ΔC-KI mice was impaired in a T-maze test. There was little difference in spatial reference memory, depression-like behavior, prepulse inhibition, or fear memory between ΔC-KI and wild-type mice. These results suggest that CTR-dependent Reelin functions are required for some specific normal brain functions and that ΔC-KI mice recapitulate some aspects of neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Comportamento Social / Comportamento Animal / Encéfalo / Serina Endopeptidases / Moléculas de Adesão Celular Neuronais / Proteínas da Matriz Extracelular / Transtornos Mentais / Proteínas do Tecido Nervoso Limite: Animais Idioma: Inglês Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Japão