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Tumor Cell Detection by Mass Spectrometry Using Signal Ion Emission Reactive Release Amplification.
Baird, Zane; Pirro, Valentina; Ayrton, Stephen; Hollerbach, Adam; Hanau, Cathleen; Marfurt, Karen; Foltz, Mary; Cooks, R Graham; Pugia, Michael.
Afiliação
  • Baird Z; Siemens Healthcare Diagnostics , 3400 Middlebury Street, Elkhart, Indiana 46516, United States.
  • Pirro V; Chemistry Department, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907-2084, United States.
  • Ayrton S; Chemistry Department, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907-2084, United States.
  • Hollerbach A; Chemistry Department, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907-2084, United States.
  • Hanau C; Chemistry Department, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907-2084, United States.
  • Marfurt K; Siemens Healthcare Diagnostics , 3400 Middlebury Street, Elkhart, Indiana 46516, United States.
  • Foltz M; Siemens Healthcare Diagnostics , 3400 Middlebury Street, Elkhart, Indiana 46516, United States.
  • Cooks RG; Siemens Healthcare Diagnostics , 3400 Middlebury Street, Elkhart, Indiana 46516, United States.
  • Pugia M; Chemistry Department, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907-2084, United States.
Anal Chem ; 88(14): 6971-5, 2016 07 19.
Article em En | MEDLINE | ID: mdl-27351295
ABSTRACT
A method is presented for the detection of circulating tumor cells (CTC) using mass spectrometry (MS), through reporter-ion amplification. Particles functionalized with short-chain peptides are bound to cells through antibody-antigen interactions. Selective release and MS detection of peptides is shown to detect as few as 690 cells isolated from a 10 mL blood sample. Here we present proof-of-concept results that pave the way for further investigations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Separação Celular / Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz / Células Neoplásicas Circulantes Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Anal Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Separação Celular / Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz / Células Neoplásicas Circulantes Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Anal Chem Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos