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Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development.
Morissette, P; Regan, C; Fitzgerald, K; Gerenser, P; Travis, J; Wang, S; Fanelli, P; Sannajust, F.
Afiliação
  • Morissette P; SALAR-Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA, USA. Electronic address: pierre_morissette@merck.com.
  • Regan C; SALAR-Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA, USA.
  • Fitzgerald K; SALAR-Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA, USA.
  • Gerenser P; SALAR-Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA, USA.
  • Travis J; SALAR-Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA, USA.
  • Wang S; SALAR-Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA, USA.
  • Fanelli P; SALAR-Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA, USA.
  • Sannajust F; SALAR-Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA, USA.
J Pharmacol Toxicol Methods ; 81: 171-82, 2016.
Article em En | MEDLINE | ID: mdl-27377419
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Xilazina / Agonistas alfa-Adrenérgicos / Anestesia / Ketamina / Anestésicos Dissociativos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Xilazina / Agonistas alfa-Adrenérgicos / Anestesia / Ketamina / Anestésicos Dissociativos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2016 Tipo de documento: Article