ß-Amyloid-acetylcholine molecular interaction: new role of cholinergic mediators in anti-Alzheimer therapy?
Future Med Chem
; 8(11): 1179-89, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27402297
ABSTRACT
BACKGROUND:
For long time Alzheimer's disease has been attributed to a cholinergic deficit. More recently, it has been considered dependent on the accumulation of the amyloid beta peptide (Aß), which promotes neuronal loss and impairs neuronal function. Results/methodology:
In the present study, using biophysical and biochemical experiments we tested the hypothesis that in addition to its role as a neurotransmitter, acetylcholine may exert its action as an anti-Alzheimer agent through a direct interaction with Aß.CONCLUSION:
Our data provide evidence that acetylcholine favors the soluble peptide conformation and exerts a neuroprotective effect against the neuroinflammatory and toxic effects of Aß. The present paper paves the way toward the development of new polyfunctional anti-Alzheimer therapeutics capable of intervening on both the cholinergic transmission and the Aß aggregation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetilcolina
/
Peptídeos beta-Amiloides
/
Fármacos Neuroprotetores
/
Colinérgicos
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Revista:
Future Med Chem
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Itália