[Neurodevelopmental outcome at 3 years of age of infants born at less than 26 weeks]. / Devenir à l'âge de 3ans d'une cohorte d'enfants nés à moins de 26 semaines d'aménorrhée.
Arch Pediatr
; 23(9): 927-34, 2016 Sep.
Article
em Fr
| MEDLINE
| ID: mdl-27424937
ABSTRACT
OBJECTIVE:
To describe the neurodevelopmental outcome and perinatal factors associated with favorable outcome among extremely preterm children at 3 years of age.METHODS:
All infants born before 26 weeks of gestation between 2007 and 2011, admitted to intensive care units participating in a French regional network (western PACA-southern Corsica) were included. Perinatal data were collected to assess the main neonatal morbidities. At 3 years of age, the children's neurodevelopment was assessed by trained physicians participating in the follow-up network. Children were classified according to their disability none, moderate, or severe. Using logistic regression, we determined the perinatal factors associated with the absence of disability at 3 years of age.RESULTS:
One hundred and sixty-two very preterm newborns were admitted to neonatal intensive care units. At discharge the survival rate was 62% (101). Rates of survival increased with gestational age (33% at 23 weeks, 57% at 24 weeks and 68% at 25 weeks). Among the 101 surviving extremely preterm children, 66 were evaluated at 3 years. The perinatal characteristics were not significantly different from those of the children lost to follow-up. Overall, 56% of extremely preterm children had no disability and 6% had severe disability. Cerebral palsy was diagnosed in 13% of children. At 3 years of age, the main perinatal factors associated with no disability were short duration of mechanical ventilation (OR=0.96 [0.93-0.99]; P=0.03) and complete course of prenatal corticosteroids (OR=4.7 [1.2-17.7]; P=0.02).CONCLUSION:
As mortality rates continue to decrease for very preterm infants, concerns are rising about their long-term outcome. In this high-risk population, improving perinatal care remains a challenge to improve long-term outcome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiências do Desenvolvimento
/
Lactente Extremamente Prematuro
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
Fr
Revista:
Arch Pediatr
Ano de publicação:
2016
Tipo de documento:
Article