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Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells.
Hengel, Sarah R; Malacaria, Eva; Folly da Silva Constantino, Laura; Bain, Fletcher E; Diaz, Andrea; Koch, Brandon G; Yu, Liping; Wu, Meng; Pichierri, Pietro; Spies, M Ashley; Spies, Maria.
Afiliação
  • Hengel SR; Department of Biochemistry, University of Iowa, Iowa City, United States.
  • Malacaria E; Department of Environment and Health, Section of Experimental and Computational Carcinogenesis, Istituto Superiore di Sanita, Rome, Italy.
  • Folly da Silva Constantino L; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, Iowa City, United States.
  • Bain FE; Department of Biochemistry, University of Iowa, Iowa City, United States.
  • Diaz A; Department of Biochemistry, University of Iowa, Iowa City, United States.
  • Koch BG; Department of Biochemistry, University of Iowa, Iowa City, United States.
  • Yu L; Department of Biochemistry, University of Iowa, Iowa City, United States.
  • Wu M; NMR Core Facility, Carver College of Medicine, University of Iowa, Iowa City, United States.
  • Pichierri P; Department of Biochemistry, University of Iowa, Iowa City, United States.
  • Spies MA; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, Iowa City, United States.
  • Spies M; High Throughput Screening Facility, University of Iowa, Iowa City, United States.
Elife ; 52016 07 19.
Article em En | MEDLINE | ID: mdl-27434671
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA de Cadeia Simples / Proteína BRCA2 / Inibidores Enzimáticos / Proteína Rad52 de Recombinação e Reparo de DNA Limite: Humans Idioma: En Revista: Elife Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA de Cadeia Simples / Proteína BRCA2 / Inibidores Enzimáticos / Proteína Rad52 de Recombinação e Reparo de DNA Limite: Humans Idioma: En Revista: Elife Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido