[Transformation of secondary myelodysplastic syndrome to atypical chronic myeloid leukemia in a female patient with acute myeloid leukemia]. / Transformatsiya vtorichnogo mielodisplasticheskogo sindroma v atipichnyi khronicheskii mieloleikoz u bol'noi ostrym mieloidnym leikozom.
Ter Arkh
; 88(7): 104-108, 2016.
Article
em Ru
| MEDLINE
| ID: mdl-27459623
ABSTRACT
Secondary myeloid neoplasia may be a complication of intensive cytostatic therapy. The most common types of secondary neoplasias are acute myeloid leukemia and myelodysplastic syndrome. The development of secondary atypical chronic myeloid leukemia (aCML) is an extremely rare phenomenon. The paper describes transformation of secondary myelodysplastic syndrome to aCML 6 months after its diagnosis. The development of aCML was accompanied by additional chromosomal aberration as monosomy of chromosome 17. No mutations in the JAK2, MPL, and CalR genes were detected. It is concluded that the clinical course of secondary myeloid neoplasias is variable.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Mielodisplásicas
/
Leucemia Mieloide Aguda
/
Leucemia Mieloide Crônica Atípica BCR-ABL Negativa
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
Ru
Revista:
Ter Arkh
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Federação Russa