Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats.
Biomed Pharmacother
; 82: 660-8, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27470409
ABSTRACT
Obesity is a serious health problem that increases the risk of many complications, including diabetes and cardiovascular disease. This study aims to evaluate, for the first time, the effects of oxaziridine 3 on lipoprotein lipase activity in the serum of rats fed with a high-fat diet (HFD) on body weight, lipid profile and liver-kidney functions. The administration of oxaziridine 3 to HFD-rats lowered body weight and inhibited the lipase activity of obese rats leading to notable decrease of T-Ch, TGs and LDL-Ch levels accompanied with an increase in HDL-Ch concentration in serum. Moreover, the findings of this study revealed that oxaziridine 3 helped to protect liver tissue from the appearance of fatty cysts. Additionally, oxaziridine 3 administration to HFD-rats induces antioxidant activity proven by the increase of superoxide dismutase (SOD) and catalase (CAT) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels. It also induces the protection of liver-kidney functions confirmed by a decrease in the levels of toxicity parameters in blood.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dieta Hiperlipídica
/
Isoquinolinas
/
Hipolipemiantes
Limite:
Animals
Idioma:
En
Revista:
Biomed Pharmacother
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Tunísia
País de publicação:
FR
/
FRANCE
/
FRANCIA
/
FRANÇA