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Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates.
Lourens, Anna C U; Gravestock, David; van Zyl, Robyn L; Hoppe, Heinrich C; Kolesnikova, Natasha; Taweechai, Supannee; Yuthavong, Yongyuth; Kamchonwongpaisan, Sumalee; Rousseau, Amanda L.
Afiliação
  • Lourens AC; CSIR Biosciences, Meiring Naude Road, Pretoria, 0001 Gauteng, South Africa. Amanda.Rousseau@wits.ac.za and Pharmaceutical Chemistry, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
  • Gravestock D; CSIR Biosciences, Meiring Naude Road, Pretoria, 0001 Gauteng, South Africa. Amanda.Rousseau@wits.ac.za and Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
  • van Zyl RL; Pharmacology Division, Department of Pharmacy and Pharmacology, WITS Research Institute for Malaria (WRIM), Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa.
  • Hoppe HC; CSIR Biosciences, Meiring Naude Road, Pretoria, 0001 Gauteng, South Africa. Amanda.Rousseau@wits.ac.za and Department of Biochemistry and Microbiology, Rhodes University, Grahamstown 6140, South Africa.
  • Kolesnikova N; CSIR Biosciences, Meiring Naude Road, Pretoria, 0001 Gauteng, South Africa. Amanda.Rousseau@wits.ac.za.
  • Taweechai S; BIOTEC, National Science and Technology Development Agency, Thailand Science Park, Pathumthani 12120, Thailand.
  • Yuthavong Y; BIOTEC, National Science and Technology Development Agency, Thailand Science Park, Pathumthani 12120, Thailand.
  • Kamchonwongpaisan S; BIOTEC, National Science and Technology Development Agency, Thailand Science Park, Pathumthani 12120, Thailand.
  • Rousseau AL; CSIR Biosciences, Meiring Naude Road, Pretoria, 0001 Gauteng, South Africa. Amanda.Rousseau@wits.ac.za and Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, 2050, South Africa.
Org Biomol Chem ; 14(33): 7899-911, 2016 Aug 16.
Article em En | MEDLINE | ID: mdl-27477595
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Triazinas / Desenho de Fármacos / Diaminas / Antagonistas do Ácido Fólico / Antimaláricos Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: África do Sul
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Triazinas / Desenho de Fármacos / Diaminas / Antagonistas do Ácido Fólico / Antimaláricos Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: África do Sul