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Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.
Yong, Kol Jia; Basseres, Daniela S; Welner, Robert S; Zhang, Wen Cai; Yang, Henry; Yan, Benedict; Alberich-Jorda, Meritxell; Zhang, Junyan; de Figueiredo-Pontes, Lorena Lobo; Battelli, Chiara; Hetherington, Christopher J; Ye, Min; Zhang, Hong; Maroni, Giorgia; O'Brien, Karen; Magli, Maria Cristina; Borczuk, Alain C; Varticovski, Lyuba; Kocher, Olivier; Zhang, Pu; Moon, Young-Choon; Sydorenko, Nadiya; Cao, Liangxian; Davis, Thomas W; Thakkar, Bhavin M; Soo, Ross A; Iwama, Atsushi; Lim, Bing; Halmos, Balazs; Neuberg, Donna; Tenen, Daniel G; Levantini, Elena.
Afiliação
  • Yong KJ; Cancer Science Institute, National University of Singapore, Singapore 117599, Singapore.
  • Basseres DS; Biochemistry Department, Chemistry Institute, University of São Paulo, São Paulo 05508, Brazil. Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA.
  • Welner RS; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA. Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
  • Zhang WC; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
  • Yang H; Cancer Science Institute, National University of Singapore, Singapore 117599, Singapore.
  • Yan B; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore 119074, Singapore.
  • Alberich-Jorda M; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA. Institute of Molecular Genetics of the ASCR, Prague 14200, Czech Republic.
  • Zhang J; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA.
  • de Figueiredo-Pontes LL; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA. Hematology Division, Department of Internal Medicine, Ribeirao Preto Medical School, University of São Paulo, São Paulo 14020, Brazil.
  • Battelli C; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA.
  • Hetherington CJ; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA.
  • Ye M; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA.
  • Zhang H; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA.
  • Maroni G; Institute of Biomedical Technologies, National Research Council (CNR), Pisa 56124, Italy.
  • O'Brien K; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA.
  • Magli MC; Institute of Biomedical Technologies, National Research Council (CNR), Pisa 56124, Italy.
  • Borczuk AC; Department of Pathology, Weill Cornell University Medical Center, New York, NY 10065, USA.
  • Varticovski L; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20817, USA.
  • Kocher O; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA.
  • Zhang P; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA.
  • Moon YC; PTC Therapeutics, 100 Corporate Court, South Plainfield, NJ 07080, USA.
  • Sydorenko N; PTC Therapeutics, 100 Corporate Court, South Plainfield, NJ 07080, USA.
  • Cao L; PTC Therapeutics, 100 Corporate Court, South Plainfield, NJ 07080, USA.
  • Davis TW; PTC Therapeutics, 100 Corporate Court, South Plainfield, NJ 07080, USA.
  • Thakkar BM; Cancer Science Institute, National University of Singapore, Singapore 117599, Singapore.
  • Soo RA; Cancer Science Institute, National University of Singapore, Singapore 117599, Singapore. Department of Haematology-Oncology, University of Western Australia, Crawley, Western Australia 6009, Australia.
  • Iwama A; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
  • Lim B; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore 138672, Singapore.
  • Halmos B; Division of Hematology/Oncology, Montefiore Hospital, Bronx, NY 10461, USA.
  • Neuberg D; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Tenen DG; Cancer Science Institute, National University of Singapore, Singapore 117599, Singapore. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA. elevanti@bidmc.harvard.edu csidgt@nus.edu.sg.
  • Levantini E; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Harvard Medical School, Boston, MA 02215, USA. Harvard Stem Cell Institute, Boston, MA 02215, USA. Institute of Biomedical Technologies, National Research Council (CNR), Pisa 56124, Italy. elevanti@bidmc.harvard.edu csidgt@nus.edu.sg.
Sci Transl Med ; 8(350): 350ra104, 2016 08 03.
Article em En | MEDLINE | ID: mdl-27488898
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Proteínas Proto-Oncogênicas / Proteína alfa Estimuladora de Ligação a CCAAT / Complexo Repressor Polycomb 1 / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Singapura País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Proteínas Proto-Oncogênicas / Proteína alfa Estimuladora de Ligação a CCAAT / Complexo Repressor Polycomb 1 / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Singapura País de publicação: Estados Unidos