Propranolol metabolism by Cunninghamella bainieri.
Xenobiotica
; 19(5): 539-46, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2750210
ABSTRACT
1. Incubations of racemic propranolol alone or in the presence of either quinidine or sparteine were performed with Cunninghamella bainieri. 2. Five mammalian metabolites of propranolol (4-hydroxypropranolol, desisopropyl-propranolol, 1-naphthoxylactic acid, propranolol glycol and 1-naphthoxyacetic acid) were present in unhydrolysed extracts of the incubation medium according to h.p.l.c. and g.l.c. analyses. The relative proportion of 4-hydroxypropranolol increased after enzymic treatment. 3. Propranolol not only had a fungistatic effect, but also caused morphological changes in the organism, which were accompanied by decomposition of 4-hydroxypropranolol and formation of a greenish-brown colour in the incubation medium. 4. Drug interaction experiments yielded results which paralleled those reported in mammals. 5. The findings indicate that C. bainieri may be a useful microbial model for drug disposition and interaction studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Mucorales
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Xenobiotica
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Canadá