Assessing the impact of defining a global priority research agenda to address HIV-associated tuberculosis.
Trop Med Int Health
; 21(11): 1420-1427, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27576587
ABSTRACT
OBJECTIVES:
In 2010, the WHO issued 77 priority research questions (PRQs) to address HIV-associated TB. Objective of the this study was to assess the impact of defining the research agenda in stimulating and directing research around priority research questions.METHODS:
We used number and type of scientific publications as a proxy to quantitatively assess the impact of research agenda setting. We conducted 77 single systematic reviews - one for every PRQ - building 77 different search strategies using PRQs' keywords. Multivariate logistic regression models were applied to assess the quantity and quality of research produced over time and accounting for selected covariates.RESULTS:
In 2009-2015, PRQs were addressed by 1631 publications (median 11 studies published per PRQ, range 1-96). The most published area was 'Intensified TB case finding' (median 23 studies/PRQ, range 2-74). The majority (62.1%, n = 1013) were published as original studies, and more than half (58%, n = 585) were conducted in the African region. Original studies' publication increased over the study period (P trend = <0.001). They focused more on the 'Intensified TB case finding' (OR = 2.17, 95% CI 1.56-2.93) and 'Drug-resistant TB and HIV infection' (OR = 2.12, 95% CI 1.47-3.06) areas than non-original studies. Original studies were published in journals of lower impact factor and received a smaller number of citations than non-original studies (OR = 0.54, 95% CI 0.42-0.69).CONCLUSION:
The generation of evidence to address PRQs has increased over time particularly in selected fields. Setting a priority research agenda for HIV-associated TB might have positively influenced the direction and the conduct of research and contributed to the global response to such a major threat to health.Palavras-chave
HIV-associated TB; OMS; PLHIV; TB asociada al VIH; TB associée au VIH; TB-HIV co-infection; WHO; coinfección TB-VIH; coinfection TB-VIH; establecimiento de prioridades; investigación; personas viviendo con VIH; personnes vivant avec le VIH; recherche; research priority setting; revisión sistemática; revue systématique; systematic review; établissement des priorités
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Saúde Global
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Infecções Oportunistas Relacionadas com a AIDS
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Pesquisa Biomédica
/
Prioridades em Saúde
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Trop Med Int Health
Assunto da revista:
MEDICINA TROPICAL
/
SAUDE PUBLICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido