Venom Peptides From Cone Snails: Pharmacological Probes for Voltage-Gated Sodium Channels.
Curr Top Membr
; 78: 65-86, 2016.
Article
em En
| MEDLINE
| ID: mdl-27586281
ABSTRACT
The venoms of cone snails provide a rich source of neuroactive peptides (conotoxins). Several venom peptide families have been identified that are either agonists (ι- and δ-conotoxins) or antagonists (µ- and µO-conotoxins) of voltage-gated sodium channels (VGSCs). Members of these conotoxin classes have been integral in identifying and characterizing specific neurotoxin binding sites on the channel. Furthermore, given the specificity of some of these peptides for one sodium channel subtype over another, conotoxins have also proven useful in exploring differences between VGSC subtypes. This chapter summarizes the current knowledge of the structure and function based on the results of conotoxin interactions with VGSCs and correlates the peptides with the phylogeny of the Conus species from which they were derived.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Peçonhas
/
Caramujo Conus
/
Canais de Sódio Disparados por Voltagem
Limite:
Animals
Idioma:
En
Revista:
Curr Top Membr
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália