Fbxw7ß, E3 ubiquitin ligase, negative regulation of primary myoblast differentiation, proliferation and migration.
Anim Sci J
; 88(4): 712-719, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27594513
ABSTRACT
Satellite cells attached to skeletal muscle fibers play a crucial role in skeletal muscle regeneration. During regeneration, the satellite cells proliferate, migrate to the damaged region, and fuse to each other. Although it is important to determine the cellular mechanisms controlling myoblast behavior, their regulators are not well understood. In this study, we evaluated the roles of Fbxw7 in primary myoblasts and determined its potential as a therapeutic target for muscle disease. We originally found that Fbxw7ß, one of the E3 ubiquitin ligase Fbxw7 subtypes, negatively regulates differentiation, proliferation and migration of myoblasts and satellite cells on muscle fiber. However, these phenomena were not observed in myoblasts expressing a dominant-negative, F-box deleted Fbxw7ß, mutant. Our results suggest that myoblast differentiation potential and muscle regeneration can be regulated by Fbxw7ß.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Movimento Celular
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Mioblastos Esqueléticos
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Células Satélites de Músculo Esquelético
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Ubiquitina-Proteína Ligases
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Proteínas F-Box
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Proliferação de Células
Limite:
Animals
Idioma:
En
Revista:
Anim Sci J
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Coréia do Sul
País de publicação:
AU
/
AUSTRALIA
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AUSTRÁLIA