A novel escapable social interaction test reveals that social behavior and mPFC activation during an escapable social encounter are altered by post-weaning social isolation and are dependent on the aggressiveness of the stimulus rat.
Behav Brain Res
; 317: 1-15, 2017 01 15.
Article
em En
| MEDLINE
| ID: mdl-27633556
ABSTRACT
Post-weaning social isolation (PSI) has been shown to increase aggressive behavior and alter medial prefrontal cortex (mPFC) function in social species such as rats. Here we developed a novel escapable social interaction test (ESIT) allowing for the quantification of escape and social behaviors in addition to mPFC activation in response to an aggressive or nonaggressive stimulus rat. Male rats were exposed to 3 weeks of PSI (ISO) or group (GRP) housing, and exposed to 3 trials, with either no trial, all trials, or the last trial only with a stimulus rat. Analysis of social behaviors indicated that ISO rats spent less time in the escape chamber and more time engaged in social interaction, aggressive grooming, and boxing than did GRP rats. Interestingly, during the third trial all rats engaged in more of the quantified social behaviors and spent less time escaping in response to aggressive but not nonaggressive stimulus rats. Rats exposed to nonaggressive stimulus rats on the third trial had greater c-fos and ARC immunoreactivity in the mPFC than those exposed to an aggressive stimulus rat. Conversely, a social encounter produced an increase in large PSD-95 punctae in the mPFC independently of trial number, but only in ISO rats exposed to an aggressive stimulus rat. The results presented here demonstrate that PSI increases interaction time and aggressive behaviors during escapable social interaction, and that the aggressiveness of the stimulus rat in a social encounter is an important component of behavioral and neural outcomes for both isolation and group-reared rats.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isolamento Social
/
Córtex Pré-Frontal
/
Agressão
/
Relações Interpessoais
Aspecto:
Determinantes_sociais_saude
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS